Cathryn Nagler Lab

Cathryn Nagler, Ph.D.

Bunning Food Allergy Professor

Ph.D., New York University, Sackler Institute of Graduate Biomedical Science, New York
B.A., Barnard College, Columbia University 

Google Scholar Profile

Contact: cnagler@bsd.uchicago.edu

Andrea Kemter, Ph.D.

Postdoctoral Scholar
Research:

Following the discovery of the allergy-protective effects of a mixture of Clostridia strains (Stefka & Feehley et al., 2014, PNAS), Andrea is investigating the mechanisms by which these bacteria boost intestinal barrier function and induce regulatory immune responses.

Biography: 

Andrea received her Diplom in Biology from the Rheinische Friedrich-Wilhelms-Universitaet Bonn, Germany, in 2011. She completed her Ph.D. in Evolutionary Biology, Immunology and Infection Research at the University of Edinburgh, Scotland, UK, in 2016.

Contact: akemter@uchicago.edu

Shijie Cao, PhD

Postdoctoral Scholar
Research:

Shijie is developing methods for inducing immune tolerance by targeted antigen delivery and microbiome modulation.

Biography: 

Shijie received a BS in Pharmacy from Fudan University in Shanghai, China. He completed his PhD in Bioengineering at University of Washington in Seattle in 2018. He’s currently a postdoctoral scholar co-advised by Dr. Jeffrey Hubbell and Dr. Cathryn Nagler.

Contact:  sjcao@uchicago.edu

Robert Patry, PhD

Postdoctoral Scholar
Research:

Rob studies the impact of healthy microbiota on the function of certain immune cells related to food allergy, also examining the bacterial structures and metabolites that induce these effects.

Biography:

Rob received his Ph.D. from the Department of Microbiology and the Complex Carbohydrate Research Center at the University of Georgia in 2020.

Contact:  rpatry@uchicago.edu

Lisa Maccio Maretto, PhD

Postdoctoral Scholar
Research:

Lisa studies how healthy bacteria might contribute to maintenance of GI tract tolerance in food allergy by modulating migration, differentiation or function of the different immune cell populations involved.

Biography:

Lisa received her Diplom in Biochemistry from Universidad Nacional de Córdoba, Argentina, in 2014. She completed her PhD in Chemical Sciences focused on Mucosal Immunology at the Center of Research in Clinic Biochemistry and Immunology (CIBICI) in the same University, in 2020.

Contact:  lmacciomaretto@uchicago.edu

Evelyn Campbell

Graduate Student, Committee on Microbiology
Research:

Evelyn is studying how microbial community dynamics and host cross-talk contribute to food allergy pathology and intestinal inflammation.

Biography:

Evelyn received her B.S., Biology from Rider University, New Jersey in 2016.

Contact: campbelle@uchicago.edu

Lauren “Ande” Hesser

Graduate Student, Pritzker School of Molecular Engineering
Research:

Working jointly with Dr. Hubbell and Dr. Cathryn Nagler, Ande’s project focuses on the development of microbiome modulating therapeutics for the prevention and treatment of food allergies. By targeting commensal gut bacteria and their metabolic byproducts as a source of immune modulation, she is gaining new insight into mechanisms underlying food allergies and discovering potential biotherapeutic agents.

Biography:

Ande received her B.S. in Biomedical Engineering from the University of South Carolina, Columbia, South Carolina, 2018.

Contact: lahesser@uchicago.edu

Jack Arnold

Graduate Student, National Science Foundation Fellow, Pritzker School of Molecular Engineering
Research:

Working jointly with Dr. Mark Mimee and Dr. Cathryn Nagler, Jack’s research is focused on the “microbiome engineering” of A. caccae and isolation of additional Lachnospiraceae species.

Biography:

Jack received his B.S. in Chemical and Biological Engineering from Northwestern University in Evanston, Illinois in 2019.

Contact: arnoldj@uchicago.edu

Edward Ionescu

Graduate Student, Pritzker School of Molecular Engineering
Research:

Edward is researching the effects of gut microbiota-derived secondary bile acids on the mucosal immune system, in the context of understanding oral tolerance and treating food allergies.

Biography:

Edward received his B.S.E. in Chemical Engineering from the University of Michigan in Ann Arbor, Michigan in 2020.

Contact: eionescu@uchicago.edu

Matthew Bauer

Laboratory Manager
Research:

Matt leads the lab’s effforts in intestinal microbial analysis and characterization.

Biography:

Matt has a B.S. in Biochemistry from Illinois State University. He has been working in the Nagler lab since he graduated in 2016

Contact: mbauer2@uchicago.edu

Mohamed Bashir Ph.D.

ClostraBio Project Manager
Research:

Mohamed studies the allergic responses to food antigens and is investigating the critical role of microbes in immune responses and the role of the commensal microbiota and their components in the regulation of tolerance to dietary allergens and food allergy.
The ClostraBio team uses animal models and in vitro assays to test microbiome modulating drugs under development.

Biography:

Mohamed received his BS in Food Science & Technology from the University of Alexandria, Alexandria, Egypt. He completed his MS in Analytical Biochemistry, from the University of Khartoum, Khartoum, Sudan. He completed his PhD in Protein Biochemistry/Molecular Immunology at the University of Saarland, Saarbrucken, Germany, in 1998. His PhD thesis describes the complete primary structure of the major allergenic proteins of the castor beans (Ricinus communis) and their phylogenetic relationship to other seed storage proteins and food allergens. He completed a successful NIH Post-doctoral Research Fellowship in Cellular and Molecular Immunology, in the Mucosal Immunology Laboratory at Harvard Medical School and Massachusetts General Hospital, Charlestown, MA, USA in 2005.

Contact:mbashir@uchicago.edu

Yanlin Su

ClostraBio Research Technical Assistant
Research:

As a member of the ClostraBio team, Yanlin works with Mohamed to build food allergy models to test the efficacy of ClostraBio’s microbiome modulating therapeutics.

Biography:

Biotechnology Certification, Oklahoma Community College, 2011

Contact:ysu2@uchicago.edu

Matthew Sabados

Undergraduate Research Assistant
Research:

Matthew works works with Shijie on targeted antigen delivery to induce immune tolerance.

Biography:

Matthew matriculated to the College in 2018 and is working on his B.S. in Biology.

Contact: mhsabados@uchicago.edu

Nidhi Talasani

Undergraduate Research Assistant
Research:

Nidhi works with Shijie on evaluating immune responses on food allergy mouse models.

Biography:

Nidhi graduated from Thomas Jefferson High School for Science and Technology in 2019 and is scheduled to graduate with a B.S. in Biological Sciences from the University in 2023.

Contact: nrtalasani@uchicago.edu

Anjali Mirmira

Undergraduate Research Assistant
Research:

Anjali is working with Ande on identifying a possible biomarker for food allergy. She is investigating the role of diacylglycerol (DAG) and using mass spectrometry techniques to develop an assay to measure it in fecal samples.

Biography:

Anjali is a second-year student in the college originally from Indianapolis, Indiana. She is majoring in chemistry with a minor in biological sciences.

Contact: amirmira@uchicago.edu

Alex Trickey

Undergraduate Research Assistant
Research:

Alex is working with Rob Patry to isolate individual bacterial strains from the healthy infant fecal samples to examine the mechanisms by which contribute to protection against food allergy.

Biography:

Alex is a second year student majoring in Biological Sciences.

Contactastrickey@uchicago.edu