The University of Chicago

Cathryn Nagler Lab

  • Light SH, Nagler CR. Regulation of immune responses to food by commensal microbes. Immunol Rev. 2024 Sep 16. doi: 10.1111/imr.13396. Epub ahead of print. PMID: 39285525. Full Paper Here
  • Hesser LA, Puente AA, Arnold J, Ionescu E, Mirmira A, Talasani N, Lopez J, Maccio-Maretto L, Mimee M, Nagler CR. A synbiotic of Anaerostipes caccae and lactulose prevents and treats food allergy in mice. Cell Host Microbe. 2024 Jun 14:S1931-3128(24)00191-4. Full Paper Here
  • Evelyn Campbell, Lauren A. Hesser, Roberto Berni Canani, Laura Carucci, Lorella Paparo, Robert T. Patry, Cathryn R. Nagler; A Lipopolysaccharide-Enriched Cow’s Milk Allergy Microbiome Promotes a TLR4-Dependent Proinflammatory Intestinal Immune Response. J Immunol 15 February 2024; 212 (4): 702–714. Full Paper Here
  • Kemter AM, Patry RT, Arnold J, Hesser LA, Campbell E, Ionescu E, Mimee M, Wang S, Nagler CR. Commensal bacteria signal through TLR5 and AhR to improve barrier integrity and prevent allergic responses to food. Cell Rep. 2023 Oct 31;42(10):113153. Full Paper Here
  • Wang R, Cao S, Bashir MEH, Hesser LA, Su Y, Hong SMC, Thompson A, Culleen E, Sabados M, Dylla NP, Campbell E, Bao R, Nonnecke EB, Bevins CL, Wilson DS, Hubbell JA, Nagler CR. Treatment of peanut allergy and colitis in mice via the intestinal release of butyrate from polymeric micelles. Nat Biomed Eng. 2023 Jan;7(1):38-55 Full Paper Here
  • Hwang DW, Nagler CR, Ciaccio CE. New and emerging concepts and therapies for the treatment of food allergy. Immunother Adv. 2022 Feb 4;2(1):ltac006 Full Paper Here
  • Brusilovsky M, Bao R, Rochman M, Kemter AM, Nagler CR, Rothenberg ME. Host-Microbiota Interactions in the Esophagus During Homeostasis and Allergic Inflammation. Gastroenterology. 2022 Feb;162(2):521-534.e8 Full Paper Here
  • Brough HA, Lanser BJ, Sindher SB, Teng JMC, Leung DYM, Venter C, Chan SM, Santos AF, Bahnson HT, Guttman-Yassky E, Gupta RS, Lack G, Ciaccio CE, Sampath V, Nadeau KC, Nagler CR. Early intervention and prevention of allergic diseases. Allergy. 2022 Feb;77(2):416-441 Full Paper Here
  • Cao S, Nagler CR. Interpreting success or failure of peanut oral immunotherapy. J Clin Invest. 2022 Jan 18;132(2):e155255 Full Paper Here
  • Nagler CR. Modern World Influences on the Microbiome and Their Consequences for Immune-Mediated Disease. J Immunol. 2021 Oct 1;207(7):1695-1696 Full Paper Here
  • Campbell E, Nagler CR. Fe, fi, fo, fum, I smell the diet of a healthy human. Cell. 2021 Aug 5;184(16):4107-4109 Full Paper Here
  • Hesser LA, Nagler CR. A wild approach to obesity prevention. Nat Metab. 2021 Aug;3(8):1038-1039 Full Paper Here
  • Mimee M, Nagler CR. Engineered yeast tune down gut inflammation. Nat Med. 2021 Jul;27(7):1150-1151 Full Paper Here
  • Patry RT, Nagler CR. Fiber-poor Western diets fuel inflammation. Nat Immunol. 2021 Mar;22(3):266-268 Full Paper Here
  • Bao R, Hesser LA, He Z, Zhou X, Nadeau KC, Nagler CR. Fecal microbiome and metabolome differ in healthy and food-allergic twins. J Clin Invest. 2021 Jan 19;131(2):e141935 Full Paper Here
  • Campbell E, Hesser LA, Nagler CR. B cells and the microbiota: a missing connection in food allergy. Mucosal Immunol. 2021 Jan;14(1):4-13 Full Paper Here
  • Nagler CR. Drugging the microbiome. J Exp Med. 2020 Apr 6;217(4):e20191642 Full Paper Here
  • Wesemann DR, Nagler CR. Origins of peanut allergy-causing antibodies. Science. 2020 Mar 6;367(6482):1072-1073 Full Paper Here
  • Bunker JJ, Drees C, Watson AR, Plunkett CH, Nagler CR, Schneewind O, Eren AM, Bendelac A. B cell superantigens in the human intestinal microbiota. Sci Transl Med. 2019 Aug 28;11(507):eaau9356 Full Paper Here
  • Iweala OI, Nagler CR. The Microbiome and Food Allergy. Annu Rev Immunol. 2019 Apr 26;37:377-403 Full Paper Here
  • Feehley T, Plunkett CH, Bao R, Choi Hong SM, Culleen E, Belda-Ferre P, Campbell E, Aitoro R, Nocerino R, Paparo L, Andrade J, Antonopoulos DA, Berni Canani R, Nagler CR. Healthy infants harbor intestinal bacteria that protect against food allergy. Nat Med. 2019 Mar;25(3):448-453 Full Paper Here
  • Kemter AM, Nagler CR. Influences on allergic mechanisms through gut, lung, and skin microbiome exposures. J Clin Invest. 2019 Feb 25;129(4):1483-1492 Full Paper Here
  • Kim YG, Sakamoto K, Seo SU, Pickard JM, Gillilland MG 3rd, Pudlo NA, Hoostal M, Li X, Wang TD, Feehley T, Stefka AT, Schmidt TM, Martens EC, Fukuda S, Inohara N, Nagler CR, Núñez G. Neonatal acquisition of Clostridia species protects against colonization by bacterial pathogens. Science. 2017 Apr 21;356(6335):315-319. Full Paper Here
  • Plunkett CH, Nagler CR. The Influence of the Microbiome on Allergic Sensitization to Food. J Immunol. 2017 Jan 15;198(2):581-589. Full Paper Here
  • Aitoro R, Simeoli R, Amoroso A, Paparo L, Nocerino R, Pirozzi C, di Costanzo M, Meli R, De Caro C, Picariello G, Mamone G, Calignano A, Nagler CR, Berni Canani R. Extensively hydrolyzed casein formula alone or with L. rhamnosus GG reduces β-lactoglobulin sensitization in mice. Pediatr Allergy Immunol. 2016 Dec 19. 2016: 00. Full Paper Here
  • Nutsch K, Chai JN, Ai TL, Russler-Germain E, Feehley T, Nagler CR, Hsieh CS. Rapid and Efficient Generation of Regulatory T Cells to Commensal Antigens in the Periphery. Cell Rep. 2016 Sep 27;17(1):206-20. Full Paper Here
  • Lei, Y.K., Chen, L., Wang, Y., Stefka, A.T., Nair, L., Molinero, L., Theriault, B., Aquino-Michaels, K., Sivan, A., Nagler, C.R., Gajewski, T.F., Chong, A.S., Bartman, C. and Alegre, M.L. The composition of the microbiota modulates skin allograft rejection. J Clin Invest. 2016. Jul 1;126(7):2736-44. Full Paper Here
  • Feehley T, Belda-Ferre P, Nagler CR. What’s LPS Got to Do with It? A Role for Gut LPS Variants in Driving Autoimmune and Allergic Disease. Cell Host Microbe. 2016 May 11;19(5):572-4. Full Paper Here
  • Wesemann DR, Nagler CR. The Microbiome, Timing, and Barrier Function in the Context of Allergic Disease. Immunity. 2016 Apr 19;44(4):728-38. Full Paper Here
  • Berni Canani R, Sangwan N, Stefka AT, Nocerino R, Paparo L, Aitoro R, Calignano A, Khan AA, Gilbert JA, Nagler CR. Lactobacillus rhamnosus GG-supplemented formula expands butyrate-producing bacterial strains in food allergic infants. ISME J. 2016 Mar;10(3):742-50. Full Paper Here
  • Yano JM, Yu K, Donaldson GP, Shastri GG, Ann P, Ma L, Nagler CR, Ismagilov RF, Mazmanian SK, Hsiao EY. Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis. Cell. 2015 Apr 9;161(2):264-76. Full Paper Here
  • Berni Canani R, Gilbert JA, Nagler CR. The role of the commensal microbiota in the regulation of tolerance to dietary allergens. Curr Opin Allergy Clin Immunol. 2015 Jun;15(3):243-9. Full Paper Here
  • Lax S, Nagler CR, Gilbert JA. Our interface with the built environment: immunity and the indoor microbiota. Trends Immunol. 2015 Mar;36(3):121-3. Full Paper Here
  • Feehley T, Nagler CR. Cellular and molecular pathways through which commensal bacteria modulate sensitization to dietary antigens. Curr Opin Immunol. 2014 Dec;31:79-86 Full Paper Here
  • Cao, S., Feehley, T., and Nagler, C.R. The role of commensal bacteria in the regulation of sensitization to food allergens. FEBS Lett. 2014 Nov 17;588(22):4258-66. Full Paper Here
  • Feehley T, Nagler CR. Health: The weighty costs of non-caloric sweeteners. Nature. 2014 Oct 9;514(7521):176-7. Full Paper Here
  • Stefka, A.T, Feehley, T., Tripathi, P., Qiu, J.,McCoy, K., Mazmanian, S., Seo, G-Y., Cao, S., Theriault, B, Antonopoulos, D., Zhou, L., Chang, E.B., Fu, Y-X., and C.R. Nagler. Commensal bacteria protect against food allergen sensitization.Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):13145-50. Full Paper Here
  • Feehley, T., Stefka, A.T., Cao, S. and C.R. Nagler. Microbial regulation of allergic responses to food. Semin. Immunopathol. 2012, 34: 671-688. Full Paper Here
  • Upadhyay, V., Poroyko, V., Kim, T.J., Devkota, S., Fu, S., Liu, D., , Deng, L., Nagler, C., Chang, E.B, Tang,H. and Fu, Y-F. Lymphotoxin regulates commensal responses to enable diet-induced obesity. Nat. Immunol. 2012, 13: 947-953.
  • Wang, S. Villablanca, E.J., De Calisto, J., Gomes, D.C.O., Nguyen, D.D., Mizoguchi, E., Kagan, J.C., Reinecker, H.-C., Hacohen, N., Nagler, C., Xavier, R.J., Rossi-Bergmann, B., Chen, Y-B., Blomhoff, R., Snapper, S.B. and Mora, J.R. MyD88-dependent TLR1/2 signals educate dendritic cells with gut- specific imprinting properties. J. Immunol. 2011, 187: 141-150.
  • Wang, Y., Devkota, S., Musch, M.W., Jabri, B., Nagler, C., Antonopoulos, D.A., Chervonsky, A and E.B. Chang. Regional mucosa- associated microbiota determine physiological expression of TLR2 and TLR4 in murine colon. PLoS ONE 2010, 5: e13607.
  • McBee M.E., Zeng Y, Parry N, Nagler C.R., Tannenbaum S.R. and D.B. Schauer. Multivariate modeling identifies neutrophil- and Th17-related factors as differential serum biomarkers of chronic murine colitis. PLoS ONE 2010, 5: e13277.
  • Matharu, K.S, Mizoguchi, E., Alonso, C., Nguyen D., Mingle, B., Iweala, O.I., McBee, M. Stefka, AT, Prioult, G, Haigis, K.M., Bhan, A.K., Snapper, S.B., Murakami, H, Schauer D.B. Reinecker,H.C Mizoguchi, A. and C. R. Nagler. Toll-like receptor 4-mediated regulation of spontaneous Helicobacter-dependent colitis in IL-10 deficient mice. Gastroenterology 2009, 137:1380–1390.
  • Iweala, O.I., Smith, D.S., Matharu, K.S., Sada-Ovalle, I..,DeKruyff, R.H., Umetsu, D.T., Behar, S.M and C. R. Nagler. Vaccine induced antibody isotypes are skewed by impaired CD4 T cell and invariant NKT cell effector responses in MyD88 deficient mice. J. Immunol., 2009, 183: 2252-2260.
  • Bashir, M.E.H., Louie, S., Shi, H.N. and C. Nagler-Anderson. TLR-4 signaling by intestinal microbes influences susceptibility to food allergy. J.Immunol., 2004, 172, 6978-6987.
  • Bashir, M.E.H., Andersen, P., Fuss, I.J., Shi, H.N. and C. Nagler-Anderson. An enteric helminth infection protects against an allergic response to dietary antigen. J. Immunol. 2002, 169:3284-3292.
  • Shi, H.N., Liu, H.Y. and C. Nagler-Anderson. Enteric infection acts as an adjuvant for the response to a model food antigen, J. Immunol., 2000, 165: 6174-6182.
  • Fox, J.G., Beck, P., Dangler, C.A., Whary, M.T., Wang, T.C., Shi, H.N. and C. Nagler-Anderson. Concurrent enteric helminth infection modulates inflammation, gastric immune responses, and reduces Helicobacter-induced gastric atrophy. Nature Medicine 2000; 6: 536-542.
  • Shi, H.N., Ingui, C. J., Dodge, I. and C. Nagler-Anderson. A helminth induced mucosal Th2 response alters non-responsiveness to oral administration of soluble antigen. J. Immunol. 1998;160:2449-2455.
  • Nagler-Anderson, C., Bober, L.A., Robinson, M.E., Siskind, G.W. and Thorbecke, G.J. Suppression of type II collagen induced arthritis by intragastric administration of soluble type II collagen. Proc. Natl. Acad. Sci. 1986; 83: 7443-7446.