Nagler Lab

How do immune cells in the intestinal mucosa distinguish innocuous dietary antigens and trillions of commensal bacteria from pathogenic microbes and mount an appropriate response to each?

Our laboratory is pursuing several different, but complementary, lines of research aimed at examining the mechanisms regulating non-responsiveness to these stimuli in healthy individuals and its abrogation in food allergy. Our murine disease models will provide the pre-clinical basis for future translational studies aimed ultimately at the development of novel immunotherapeutic modalities.